How does damage-seq work?

How does damage-seq work? Some kinds of DNA damage will reduce the binding affinity of histones, causing that region of DNA to become less compact. Some kinds of DNA damage will cause a distortion in the double helix, which can be detected using X-ray scattering. Some kinds of DNA damage block DNA polymerase, stopping synthesis just before the damaged nucleotide. Some kinds of DNA damage will cause a change in fluorescence when the next base is added, which can be detected by the sequencer.