Which of the following is a mechanism of action associated with cocaine?
Which of the following is a mechanism of action associated with cocaine? For example, cocaine acts by binding to the dopamine transporter, blocking the removal of dopamine from the synapse. Dopamine then accumulates in the synapse to produce an amplified signal to the receiving neurons.
| It inhibits the reuptake of dopamine. | ||
| It decreases 5 HT in the brain, while simultaneously decreasing dopamine. | ||
| It decreases 5 HT in the brain, while simultaneously increasing dopamine. |
Is cocaine a dopamine agonist or antagonist?
Cocaine is a monoamine transporter blocker and, thus, an indirect agonist of dopamine receptors. Cocaine binds the dopamine transporter (DAT), blocking the protein’s ability to uptake dopamine from the synaptic cleft and also blocking DAT from terminating dopamine signaling.
How does cocaine affect the nervous system quizlet?
Cocaine prevents dopamine from recycling, causing excessive amounts to build up between nerve cells. This flood of dopamine ultimately disrupts normal brain communication and causes cocaine’s high.
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