The pathogenesis of complex autoimmune disorders

What are the underlying genetic, environmental, and immunological factors contributing to the pathogenesis of complex autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease, and how can precision medicine approaches, including genomic profiling, biomarker discovery, and targeted immunotherapies, offer personalized treatment options and improve outcomes for patients with autoimmune conditions?