Explain the physiological mechanisms underlying the regulation of blood pressure

Can you explain the physiological mechanisms underlying the regulation of blood pressure by the renin-angiotensin-aldosterone system (RAAS) and the role of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) in hypertension management? How does the juxtaglomerular apparatus in the kidneys detect changes in blood pressure and stimulate renin release, leading to the conversion of angiotensinogen to angiotensin I and its subsequent conversion to angiotensin II by ACE? Additionally, how does angiotensin II induce vasoconstriction, aldosterone release, and sodium retention, thereby increasing blood volume and elevating blood pressure? Furthermore, how do ACE inhibitors and ARBs interfere with the RAAS to lower blood pressure and mitigate the progression of cardiovascular disease?

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